RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-29b-1
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
dual-lucimmunofluorescenceerase reporter assay; PCR; etc.
Target
TGF-B; SMAD3
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-B1/Smad3
Year
2016
Function
"Overexpression of mir-29b inhibits the expression of smad3 and tgf-b1, inhibits the expression of (a-sma) and type 1 collagen (col-1), inhibits hepatic stellate cell activation."